Personalized and Precision Medicine Journal
Where Innovations Meets Personalized and Precision Medicine

Targeted Screening of Membrane Proteins of Haemophilus Ducreyi with the Aim of Drug Targets Identification

Document Type : Original Article

Authors

Sahar Khorsand-Dehkordi 1
Farnoosh Honarmand 2
Zahra Ahmadzadeh Chaleshtori 3

1 Department of Biology, Faculty of Basic Sciences, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran.

2 Department of Biology, Faculty of Basic Sciences, Tehran Branch, University of Science and Culture, Tehran, Iran.

3 Department of Biochemistry, Falavarjan Branch, Islamic Azad University, Isfahan, Iran

https://doi.org/10.22034/pmj.2024.2024174.1032
Abstract
Chancroid is an STI characterized by the Gram-negative bacteria Haemophilus ducreyi. Controlling chancroid is challenging, and the primary treatment accessible is antimicrobial therapy. However, drug resistance has been seen in places where the disease is common. Due to recent global outbreaks of sexually transmitted infections (STIs), it is crucial to continue researchi ng innovative treatment options and prevention measures. We used reverse vaccinology and subtraction genomic methods to determine potential vaccination and therapeutic targets against H. ducreyi in silico. We found 56 Secreted proteins, with 159 membrane molecules and 515 cytoplasmic proteins. We assessed their need, operation, and ability to cause disease. We identified 6 potential vaccination targets and three pharmacological targets inside pathogenicity islands. The discovered targets may be utilized in future initiatives to manage chancroid globally.

Keywords

Sexually transmitted infections
Chancroid
H. ducreyi
Reverse vaccinology
Subjects
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Personalized and Precision Medicine Journal
Volume 9, Issue 32 - Serial Number 32
Original article
Winter 2024
Pages 8-15

  • Receive Date 30 November 2023
  • Revise Date 15 January 2024
  • Accept Date 22 February 2024

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