Personalized and Precision Medicine Journal
Where Innovations Meets Personalized and Precision Medicine

The Use of Bacteriophages in Cancer Therapy

Articles in Press

Document Type : Review Article

Author

Sanaz Khosravi

Assistant doctor, Neurology Department, 93413 Cham, Germany

10.22034/pmj.2024.2044427.1042
Abstract
Cancer is a catastrophic illness with a significant worldwide fatality rate, anticipated to rise in the next years. Contemporary treatment modalities, including chemotherapy and radiation therapy, include constraints such as adverse effects, inconsistent efficacy, elevated expenses, and restricted accessibility. Bacteriophages have arisen as multifaceted instruments in bioengineering, with significant promise in tissue engineering, vaccine formulation, and immunotherapy. Bacteriophages are being used extensively in several fields of biotechnology and medicine, with cancer treatment being the most compelling application. Numerous studies are increasingly validating the effectiveness and safety of phage-based vectors as systemic delivery vehicles for therapeutic genes and medicines in cancer treatment. Moreover, the genetic composition of phages may be used for the creation of innovative DNA vaccines and antigen display systems, since they provide a highly structured and repeated presentation of antigens to immune cells. Bacteriophages have created novel opportunities for the precise targeting of certain molecular determinants in cancer cells. Phages may serve as anticancer agents and as carriers for imaging compounds and medicines. This article introduces bacteriophage and examines the performance of bacteriophages and bacteriophage engineering in targeted cancer treatment.

Keywords

Bacteriophage
Cancer treatment
Cancer vaccine
Phage display

Subjects

Personalized and Precision Medicine Journal

Articles in Press, Accepted Manuscript
Available Online from 28 October 2024

  • Receive Date 28 October 2024

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