Personalized Medicine Journal

Relationship between recurrence pregnancy loss and microRNA expression

Hadi Yari; kazhaleh Mohammadi; Mohammad Ali Keshavarz Shahbaz; Vahid Reza Esfahani

Volume 5, Issue 18 , September 2020, , Pages 7-10

https://doi.org/10.22034/pmj.2020.46379

Abstract

The miRNAs produced predominantly in the placenta are probably involved in placental differentiation and maintenance of pregnancy. One of the important functions of miR-126 is its involvement ... Read More

miR-146a rs2910164 polymorphism and lung cancer in a Tehran population

Niloofar JAHANGIR SOOLTANI; Hossein Pakzad; Mohammad Ali Saremi

Volume 5, Issue 18 , September 2020, , Pages 10-13

https://doi.org/10.22034/pmj.2020.46380

Abstract

Lung cancer is still the most common cancer worldwide in terms of the number of newly diagnosed cases and mortality rate. The expression of miR-146a was reduced in mesenchymal-like ... Read More

Role of personalized microRNA-124 Expression in Ovarian Cancer

Babak Otoukesh; Peyman Kaghazian; Amirjouya Talaei; Bahram Boddouhi; Bahareh Heshmat

Volume 4, Issue 13 , June 2019, , Pages 1-5

https://doi.org/10.21859/pmj04011

Abstract

Introduction: MicroRNA-124 (miR-124) is moderated in some human malignancies and is associated with tumor advancement. But, its expression and clinical importance in ovarian carcinoma ... Read More Introduction: MicroRNA-124 (miR-124) is moderated in some human malignancies and is associated with tumor advancement. But, its expression and clinical importance in ovarian carcinoma is still unclear. Thus, the goal of this study was to feature the clinical importance of personalized miR-124 expression in ovarian carcinoma. Methods: 94 women ovarian cancer tissues and 26 normal ovarian tissues were accumulated from patients. We used Real-time PCR to quantify the expression of personalized miR-124 in clinical ovarian carcinoma specimen and normal tissues. Moreover, we measured the miR-124 relationship with clinicopathologic characteristics and the ovarian carcinoma survival. Results: The lesser expression of miR-124 in tumor tissues can be found in compared with normal tissue using PCR method (P < 0.05). Our data exhibited that there is a notable association among low expression of miR-12 and clinical staging of ovarian carcinoma (P = 0.023). Nevertheless, miR-124 expression was not notably associated with age (P = 0. 671), differentiation status (P = 0.512), lymph node metastasis (P = 0.415) and histological subtypes (0.547). Kaplan-Meier survival analysis and log-rank test were applied in present study. These tests showed the less expression on patients had markedly short-term survival time in comparison with high expression group (P = 0.022). Multivariate Cox proportional hazards model analysis revealed that less expression of miR-124 and clinical staging were contribute to short-term survival in patients with ovarian carcinoma. The HR of the low miR-124 expression group was calculated to be 2.532 (95% CI: 1.572-9.237, P = 0.021), (clinical staging HR: 2.532; 95% CI: 1.321-9.241, P = 0.032).Conclusions: These findings suggested that personalized miR-124 could be considered as an independent prognostic factor for ovarian carcinoma patients. Our findings suggested that low expression of personalized miR-124 has prognostic worthiness in ovarian.

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Keywords = MicroRNA

Relationship between recurrence pregnancy loss and microRNA expression

Abstract

miR-146a rs2910164 polymorphism and lung cancer in a Tehran population

Abstract

Role of personalized microRNA-124 Expression in Ovarian Cancer

Abstract