Document Type : Original Article
Human Genetics Division, Medical Biotechnology Department, National Institute of Genetics Engineering and Biotechnology, Tehran, Iran.
Researcher and lecture assistant at the Medical Laboratory Science Department, Knowledge University, Kurdistan Region, Erbil, Iraq
Human Genetics Division, Medical Biotechnology Department, National Institute of Genetics Engineering and Biotechnology, Tehran, Iran
Personalized Medicine Research Center of AmitisGen, Tehran, Iran
The miRNAs produced predominantly in the placenta are probably involved in placental differentiation and maintenance of pregnancy. One of the important functions of miR-126 is its involvement in angiogenesis by enhancing the expression of VEGF. Abnormalities of placental vasculature may result in several gestational complications, including pregnancy loss. The current study compared the expression of miR-126 in the plasma of women with recurrent miscarriages and women with healthy pregnancies by Realtime qRT-PCR. The results indicated that the expression difference of miR-21 between the pregnant patients and the controls was statistically significant (p =0.002). This microRNA can be used as a biomarker in diagnosis and progression.
- Wilcox AJ, Weinberg CR, O'Connor JF, Baird DD, Schlatterer JP, et al. (1988) Incidence of early loss of pregnancy. N Engl J Med 319: 189–194.
- Stirrat GM (1990) Recurrent miscarriage. II: Clinical associations, causes, and management. Lancet 336: 728–733.
- Practice Committee of the American Society for Reproductive Medicine (2012) Evaluation and treatment of recurrent pregnancy loss: a committee opinion. Fertil Steril
- an Q, Luo X, Toloubeydokhti T, Chegini N (2007) The expression profile of micro-RNA in endometrium and endometriosis and the influence of ovarian steroids on their expression. Mol Hum Reprod 13: 797–806.
- Bin, Y., Tianmei, Q., Yongjun, W., Songlin, Z., Guohui D., Fei, D., Xiaosong G. (2012). miR-182 inhibits Schwann cell proliferation and migration by targeting FGF9 and NTM, respectively at an early stage following sciatic nerve injury. Nucleic Acids Research, 40(20): 10356-10365.
- Chakrabarty, A., Tranguch, S., Daikoku, T., Jensen, K., Furneaux, H., Dey, S.K. (2007). MicroRNA regulation of cyclooxygenase-2 during embryo implantation. Proceedings of NationalAcademy of Science(USA), 104 (38): 15144-15149.
- Dai, Y., Diao, Z., Sun, H., Li, R., Qiu, Z., Hu, Y. (2011). MicroRNA-155 is involved in the remodelling of human-trophoblast-derived HTR8/SVneo cells induced by lipopolysaccharides. Human Reproduction, 26(7):1882-1891.
- Practice Committee of the American Society for Reproductive Medicine. Definitions of infertility and recurrent pregnancy loss. Fertil Steril. 2008; 90(5 Suppl):S60.
- Amin-Beidokhti M, Mirfakhraie R, Zare-Karizi S, Karamoddin F. The role of parental microRNA alleles in recurrent pregnancy loss: an association study. Reprod Biomed Online. 2016: 34(3):325–30
- Fu G., Brkic J., Hayder H., Peng C. (2013). MicroRNAs in Human Placental Development and Pregnancy Complications. International Journal of Molecular Sciences 14, 5519-5544.
- Renthal, N.E., Chen, C.C., Williams, K.C., Gerard, R.D., Prange-Kiel J., Mendelson C.R. (2010). miR200 Family and targets, ZEB1 and ZEB2, modulate uterine quiescence and contractility during pregnancy and labor. Proceedings of National Academy of Science (USA),107(48):20828-20833.
- Hong, X., Luense, L.J., McGinnis, L.K., Nothnick, W.B., Christenson, L.K.(2008). Dicer1 is essential for female fertility and normal development of the female reproductive system. Endocrinology 149 (12), 6207-6212.
- Morita, S., Horii, T., Kimura, M., Goto, Y., Ochiya, T., Hatada, I. (2007). One Argonaute family member. Eif2c2 (Ago2), is essential for development and appears not to be involved in DNA methylation. Genomics, 89 (6):687-696.
- Sun, H.X., Zeng D.Y., Li, R.T., Pang, R.P., Yang, H., Hu, Y.L., Zhang, Q., Jiang, Y., Huang, L.Y., Tang, Y.B., Yan, G.J., Zhou, J.G. (2012). Essential role of microRNA-155 in regulating endothelium-dependent vasorelaxation by targeting endothelial nitric oxide synthase. Hypertension, 60(6):1407-1414.