Personalized and Precision Medicine Journal

Abstract Genetic studies, there is a potential association of RELN with some psychological
disorders such as Autism Spectrum Disorders (ASD) schizophrenia (SCZ). The RELN
gene is located on chromosome 7q22.1 and encodes a large secretory protein of the
extracellular matrix (Reelin). In the present case-control study, we intended to investigate
the relationship between the rs362746 polymorphism of RELN and schizophrenia in a
group of schizophrenic and healthy subjects from northeastern Iran.30 unrelated schizophrenic patients and 30 matched control subjects were recruited The samples
from the participants underwent PCR and sequencing for RELN genotype identification.he genotype distribution for  both study and control groups were not in Hardy–Weinberg equilibrium(P>0.05).However, it was found that the prevalence of
rs362746 polymorphism was significantly different between the groups. the present study supported the evidence that rs362746 polymorphism of RELN was a
genetic factor for schizophrenia susceptibility. However, there is a need for replication
studies on different populations and further investigations on the sex-specific association
of this gene with schizophrenia.

Abstract Lung cancer is the leading cause of cancer deaths worldwide. Approximately 25% of nonsmall-cell lung cancers have mutations in the EGFR gene, most of which occur in hotspot regions in exons 18, 19, 20, and 21. In-frame deletions in exon 19 (~50%) and the L858R point mutation in exon 21 (~40%) are associated with a favorable response to EGFR tyrosine kinase inhibitors. In this study, mutations of two exons of 19 and 21 in 50 lung cancer tumor samples were investigated by the sequence method. From 50 lung cancer patients, 8 (16%) patients had an L858R (c.2573T>G) mutation, 6 (12%) patients had deletion type 1a mutation, and one patient had deletion type 1b mutation. Examining the sequence of candidate genes associated with lung cancer can be very important in choosing the right treatment approach.