Personalized Medicine Journal

SIRT1 rs7895833 and SOD1-50bp ins/del Gene vVariations in Age-Related Cataract Patients: A Case-Control Study

Leila Kohan; Sahar Sharghi; Afshin Karimi

Volume 9, Issue 32 , March 2024, , Pages 16-22

https://doi.org/10.22034/pmj.2024.2024055.1029

Abstract

Aim: Oxidative stress is one of the main factors has been implicated in pathophysiology of cataracts. Superoxide dismutase (SOD) can prepare the first line of defense versus detrimental ... Read More Aim: Oxidative stress is one of the main factors has been implicated in pathophysiology of cataracts. Superoxide dismutase (SOD) can prepare the first line of defense versus detrimental reactive oxygen species (ROS) and Sirtuin (SIRT) confers protection against oxidative stress and retinal degeneration. Correlation of SOD1-50bp ins/del and SIRT1-rs7895833 polymorphisms with risk of cataracts is not studied currently. Therefore, we aimed to explore possible relationship between SOD1 (50bp ins/del) and SIRT1 (rs7895833) polymorphisms with the risk of cataracts in Iranian population. Methods: Our study design consisted of 200 patients with age-related cataracts and 200 healthy individuals as a control group. After DNA extraction, the identification of polymorphisms was conducted using PCR-based methods and data analysis was done by SPSS software. Results: A significant difference in SOD1 DD genotype distribution was observed between studied groups (OR: 3.42, P:0.037), the D allele was more frequent in patients in comparison with controls (OR: 1.68, P:0.009). Also, in the dominant genetic model for the D allele (comparison between ID+DD vs. II), ID+DD genotypes increased the risk of cataracts (OR: 1.62, P: 034). The association between SIRT1-rs7895833 polymorphism and cataract was significant in the AG genotype (OR: 2.37, P<0.001) and G allele (OR: 1.97, P<0.001). The SIRT1-1 polymorphism increased the risk of cataracts in the dominant tested inheritance model (OR: 2.34, P<0.001). In the combined analysis of two polymorphisms, there is an additive effect of the high-risk putative alleles about the risk of cataracts. Risk estimation according to the number of high-risk alleles showed that χ2 for linear trend for 0, 1, 2, 3 and 4 putative high-risk alleles is equal to 20.10 (P<0.001). Conclusion: The results showed that for the first time, SIRT1 rs7895833 and SOD1-50bp ins/del gene variations had additive effects on the risk of cataracts.

In Silico Studies of Chemical Compounds from Punica Granatum›s Peel as Angiotensin-I Converting Enzyme Inhibitor

Seyed Pouyan Pishva; Asghar Davood; Maryam Iman

Volume 8, Issue 31 , December 2023, , Pages 35-40

https://doi.org/10.22034/pmj.2023.2017681.1022

Abstract

Present research on herbal food-derived phenolic compounds as angiotensin-I-converting enzyme (ACE) inhibitors has been well-documented. Punica granatum L. (pomegranate) is considered ... Read More

Proinflammation and inflammatory cytokine gene expression changes in human macrophages infected by L. major

Khoda Berdi Kalavi; Ghorbanmohammad Kochaki; Kamran Eghbalpour; Nahid Eghbalpour

Volume 8, Issue 31 , December 2023, , Pages 51-54

https://doi.org/10.22034/pmj.2023.2018677.1027

Abstract

Background: Leishmania Species produced diseases include clinical problems from cutaneous self-limiting to severe non-healing forms such as visceral leishmaniasis (VL). As an obligatory ... Read More

Personalized Medicine for HIV Control: A Systematic Review Study

Shekoofeh Farahmandpour; Nastaran Dehghani; Asra Khalkhalizadeh; Paniz Hajihossein; Armin Nikdehqan

Volume 8, Issue 30 , September 2023, , Pages 9-16

https://doi.org/10.22034/pmj.2023.2011747.1015

Abstract

There were more than thirty-eight million HIV infections worldwide. Combination antiretroviral therapy (cART) has progressed to the point where invisible viral loads are now feasible, ... Read More

Targets for Anti-HIV-1 Agents as Personalized HIV Therapy: A Review Study

Mina Jafari; Ava Shamipak; Fateme Shahsavari; Armin Nikdehqan; Paniz Hajihossein

Volume 8, Issue 30 , September 2023, , Pages 25-31

https://doi.org/10.22034/pmj.2023.2011750.1016

Abstract

The enormous genetic variety of the viral population harbored by the patient and the large volume of therapeutic alternatives characterize HIV therapy. Each patient and period has its ... Read More

Pathogenesis of Autoimmune Thyroid Disease (AITD) in Type 1 Diabetes: The Role of Autoantibodies (anti-TPO and anti-TG) and Cytokines (IL-10, IL-6, and TNF-α)

Ali Neamati; Parisa Sanati; Sahar Abareshi

Volume 8, Issue 30 , September 2023, , Pages 41-47

https://doi.org/10.22034/pmj.2023.2011813.1017

Abstract

Objectives: Diabetes mellitus type 1 (T1DM), which is also an autoimmune disorder, can coexist alongside other types of autoimmune diseases. This study aimed to investigate the possibility ... Read More

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Main Subjects = Molecular Medicine

SIRT1 rs7895833 and SOD1-50bp ins/del Gene vVariations in Age-Related Cataract Patients: A Case-Control Study

Abstract

In Silico Studies of Chemical Compounds from Punica Granatum›s Peel as Angiotensin-I Converting Enzyme Inhibitor

Abstract

Proinflammation and inflammatory cytokine gene expression changes in human macrophages infected by L. major

Abstract

Personalized Medicine for HIV Control: A Systematic Review Study

Abstract

Targets for Anti-HIV-1 Agents as Personalized HIV Therapy: A Review Study

Abstract

Pathogenesis of Autoimmune Thyroid Disease (AITD) in Type 1 Diabetes: The Role of Autoantibodies (anti-TPO and anti-TG) and Cytokines (IL-10, IL-6, and TNF-α)

Abstract