Document Type : Review Article


1 ATMP Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR,Tehran, Iran

2 Department of Cellular and Molecular Tehran Medical Sciences Branch,lslamic Azad University, Tehran, Iran



Severe Acute Respiratory Syndrome
Coronavirus 2 (SARS-CoV-2), is a severe infection with respiratory and systemic
manifestations. This infectious disease has a complex course and manifests itself with
various clinical presentations, ranging from asymptomatic infection to a severe clinical
course. These variations in severity have raised the question of whether the genetic or
epigenetic variations have a role in COVID-19 susceptibility or severity, and that these
factors can be used to predict the disease course. A whole-genome sequencing performed
on 95 samples of SARS-CoV-2 identified 116 unique mutations, most of which were
missense and synonymous. Moreover, some studies have reported a relationship between
the COVID-19 severity and the genes ACE and TMPRSS2. The present review provides
an overview of different genes that have been found to be implicated or related to the
susceptibility to COVID-19 or its severity.