Document Type : Review Article

Authors

• Rafid A Abdulkareem ¹
• Seyed Majid Hashemi Fard ²
• Masoomeh Kohandani ³

¹ Genetic engineering and biotechnology Institute, Baghdad University, Iraq.

² AmitisGen Lab, Food and Drug Administration of Iran Ministry of Health and Medical Education. Tehran, Iran

³ Master of Science in Cellular and Molecular Biology, Department of cell and Molecular Biology, Karazmi University, Tehran, Iran

Abstract

Prostate cancer (PCa) is the most common solid tumor in men. While patients with local PCa have better prognostic survival, patients with metastatic PCa have relatively high mortality rates. Exosomes (and other extracellular vesicles) are now part of the cancer research landscape, involved both as players in pathophysiological mechanisms, as biomarkers of the cancer process, and as therapeutic tools. Exosomes contain miRNAs, mRNAs, and proteins with the potential to regulate signaling pathways in recipient cells. Accumulating evidence indicates that exosomes play important roles in cell communication and tumor progression and are suitable for monitoring PCa progression and metastasis.