Personalized and Precision Medicine Journal
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A Review of Exosomes: Isolation Methods and Applications

Document Type : Review Article

Authors

Mahshid javanbakht 1
Mohammad Amin Niknezhad 2
Hanieh Rezvani 3

1 Department of Genetics, Faculty of Basic Sciences, University of Guilan, Guilan, Iran.

2 Department of Microbiology, Islamic Azad University of Shahrekord, Shahrekord, Iran.

3 Department of Genetics, Islamic Azad University of Shahrekord, Shahrekord, Iran.

https://doi.org/10.22034/pmj.2024.718048
Abstract
Exosomes are becoming recognized as crucial facilitators of interaction between cells. They deliver biological agents to target cells, play essential roles throughout multiple biological and pathological events, and have significant potential as innovative alternative therapies for illnesses. Exosomal communication between cells appears to have a role in the development of several illnesses, involving cancer, neurodegenerative conditions, and inflammatory disorders. Exosomes are diminutive (20–150 nm) entities characterized by a unique bilipid protein architecture. They transport and switch diverse cargos across cells and serve as noninvasive indicators for multiple disorders. Exosomes are regarded as the most effective indicators for cancer detection due to their distinctive properties. This document will examine the current uses of exosomes, their origins, and diverse isolation techniques. Furthermore, the function of exosomes and their use in biomedical studies and preclinical experiments are succinctly addressed.

Keywords

Exosome therapy
Biomarker
Extracellular vesicles
Drug delivery
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Personalized and Precision Medicine Journal
Volume 9, Issue 35 - Serial Number 35
Original article
Autumn 2024
Pages 33-43

  • Receive Date 03 August 2024
  • Revise Date 22 October 2024
  • Accept Date 23 November 2024

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