Personalized and Precision Medicine Journal

Abstract Pharmacogenomics is the application of genetic and other omics data to specific medication selection and application for avoiding adverse drug reactions (ADR) and increasing drug potency. Pharmacists are playing an increasingly important role in optimizing medicine usage based on genetic testing results. Effect elucidation, genotype-guided medication and modification, medication asset, adverse reaction monitoring, and patient education are all tasks performed by pharmacists. Microbial invasion leads to infectious diseases, which have afflicted mankind from the early era, and is still impacting the health and one of the major causes of morbidity as well as mortality in the society. The response to therapy and the prognosis of an illness are also influenced by an individual’s genetic makeup. The data retrieved by genome sequencing of pathogen and humans is one further step forward in examining host-parasite interactions. Consideration of microbial pathogenicity factors, host genetic makeup, and the genetic mechanism involved in disease pathogenesis has paved the way for novel molecular approaches for medications, disease markers, and vaccinations to be discovered. The regulatory approval of amplification tests that are comparable or patronizing to existing gold standard procedures is now assisting the advancement of molecular diagnostics for infectious diseases. Progress in genetics and computation is altering the scale at which biological systems are depicted, and researchers may now expect a precision-focused variety in how they prepare for and respond to infectious diseases. This review will look at the origins and evolution of pharmacogenomics, as well as some of the controversies surrounding its therapeutic applications.

Abstract The current study identified pathogenic variables associated with increased mortality risk in infectious diseases using predictive analysis and a combination of genotypic, phenotypic, and medical data. The quick nucleic acid-based clinical assessment might affect the spread of hospital-acquired illnesses, and we think that such life-saving operations should be carried out closer to the individual, preferably in 24/7 medical facilities' specialized labs. Personalized medicine notions are relevant in infections for the (rapid) characterization of a disease-causing microbial community and perseverance of its antibiotic susceptibility characteristic to guide a suitable antibiotic therapy for the proper care of the individual. Personalized medicine aims to interrogate a patient's genetic data, and pharmacodynamics polymorphisms, and guide drug options and dosage. This work demonstrates the potential use of fundamental genetic analysis in treating infectious diseases and theoretically justifies the value of customized therapy