Document Type : Original Article

Authors

• Maryam Hassanpoor ¹
• Bahareh Abbasi ²

¹ Department of cell and molecular biology,Faculty of biological sciences, Kharazmi university, Tehran, Iran

² National Institute of Genetic Engineering and Biotechnology.

Abstract

Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune. Early diagnosis of RA remains challenging. A significant portion of RA patients also experience unremitting symptoms despite treatment. miRNA are involved in the regulation of autoimmunity- and inflammation-related processes. In this study, we evaluated the expression of miR-22-3p in serum of RA patients as a novel biomarker. Expression level of this gene in the blood serum of 30 people with RA compared with 30 healthy individuals by the qRT-PCR method. Results showed levels of miR22-3p were significantly higher in the serum of patients with RA in comparison with healthy control (p<0.0001). We suggest that miR 22-3p can be used as a biomarker in early detection and screening.

Keywords

• Rheumatoid arthritis (RA)
• micro RNA
• miR 22-3p
• gene expression
• Autoimmune disease