Personalized and Precision Medicine Journal
Where Innovations Meets Personalized and Precision Medicine

Effect of ascorbic acid treatment with angiogenesis

Document Type : Original Article

Authors

Sareh Bakhshandeh Bavarsad 1
Amir Mohammadi 2
Najme Shojaei 3

1 Department of public management, Faculty of management, University of Shahrekord, Iran

2 Department of Immunology, Asthma and Allergy Research Institute, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran

3 Personalized Medicine Research Center of AmitisGen, Tehran, Iran

https://doi.org/10.22034/pmj.2020.46382
Abstract
Vitamin C plays is a cofactor for enzymes involved in many processes and has effects that are important for cancer transformation, such as antioxidant defense, transcription, and epigenetic regulation of gene expression.Angiogenesis is a normal process required for normal tissue repair and growth. Pathological angiogenesis is characterized by the persistent proliferation of endothelial cells and formation of blood vessels.The current study evaluated the effect of ascorbic acid on angiogenesis by investigating the expression of genes related to angiogenesis after treatment with different doses of ascorbic acid. By changing the concentration and administration time of ascorbic acid, a positive effect on the growth and metastasis of cancer cells in the group injected with ascorbic acid prior to having cancer cells injected into the abdominal cavity .



 

Keywords

Vitamin C
Angiogenesis
carcinostatic
Breast cancer
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Personalized and Precision Medicine Journal
Volume 5, Issue 18
Original article
Summer 2020
Pages 17-19

  • Receive Date 21 October 2020

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